Journal article

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders

T Takahashi, SJ Wood, AR Yung, B Nelson, A Lin, HP Yuen, LJ Phillips, M Suzuki, PD McGorry, D Velakoulis, C Pantelis

Schizophrenia Research | ELSEVIER | Published : 2022

DOI: 10.1016/j.schres.2022.04.005

Abstract

Background: Pineal volume reductions have been reported in schizophrenia and clinical high-risk states for the development of psychosis, supporting the role of melatonin dysregulation in the pathophysiology of psychosis. However, it remains unclear whether pineal volume is associated with the later onset of psychosis in individuals at clinical high-risk (CHR) of psychosis or if pineal atrophy is specific to schizophrenia among different psychotic disorders. Methods: This magnetic resonance imaging study examined the volume of and cyst prevalence in the pineal gland in 135 individuals at CHR of psychosis [52 (38.5%) subsequently developed psychosis], 162 with first-episode psychosis (FEP), 89..

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University of Melbourne Researchers

Stephen Wood Author

Barnaby Nelson Author

Hok Yuen Author

Lisa Phillips Author

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2Web of Science

Keywords

2.3 Psychological, Social and Economic Factors

Science & Technology

Clinical Research

Clinical High-Risk

32 Biomedical and Clinical Sciences

Brain Disorders

2.1 Biological and Endogenous Factors

Ultra-High-Risk

3214 Pharmacology and Pharmaceutical Sciences

Life Sciences & Biomedicine

Serious Mental Illness